Table 2.
Demographics, RHC, Echocardiography and CMR Data
| No PH n = 39 | PH n = 194 | |
|---|---|---|
|
Demographics | ||
| Age (yrs) |
61 ± 16 |
63 ± 15 |
| Female (%) |
56% |
59% |
| WHO class I |
|
3 (1.5%) |
| II |
|
42 (21.6%) |
| III |
|
127 (65.5%) |
| IV |
|
22 (11.3%) |
|
Invasive catheter measurements | ||
| mRAP (mmHg) |
6 ± 3 |
11 ± 5† |
| mPAP (mmHg) |
19 ± 3 |
45 ± 12† |
| PCWP (mmHg) |
11 ± 5 |
12 ± 6 |
| CO (L.min) |
7.0 ± 1.8 |
5.1 ± 1.7† |
| CI (L.min.m-2) |
3.7 ± 0.7 |
2.9 ± 0.9† |
| PVR (dyn.s.cm-5) |
149 ± 167 |
587 ± 411† |
| Mixed VO2 (%) |
73.5 ± 6.3 |
63.8 ± 9.2† |
|
Echocardiography (n = 195) | ||
| TRJV (cm/s) |
2.6 ± 0.6 |
3.9 ± 0.9† |
| Echo derived mPAP (mmHg) |
25.4 ± 7.6 |
46.8 ± 16.6† |
|
MR – RV morphology | ||
| RVEDVI (ml/m2) |
77.7 ± 24.6 |
99.1 ± 39.0† |
| RV mass index (g/m2) |
13.7 ± 6.92 |
37.6 ± 18.7† |
| VMI (ratio) |
0.26 ± 0.11 |
0.70 ± 0.35† |
| Late gadolinium enhancement, ratio and % (n = 159) |
2/31 (6%) |
108/128 (86%) |
|
MR – RV function | ||
| RVEF (%) |
39.7 ± 14.5 |
28.2 ± 14.5† |
| RVSVI (ml/m2) |
31.4 ± 13.3 |
23.3 ± 13.2† |
| TAPSE (cm) |
2.21 ± 0.66 |
1.55 ± 0.76† |
| f-TAAD (%) |
24.6 ± 7.89 |
15.9 ± 7.49† |
| SFD (cm) |
1.10 ± 0.45 |
0.64 ± 0.52† |
| f-SFD (%) |
27.1 ± 11.5 |
14.4 ± 12.3† |
| RVRAC (%) |
39.8 ± 10.5 |
26.2 ± 13.4† |
| sEI (ratio) |
1.19 ± 0.19 |
1.57 ± 0.52† |
| dEI (ratio) |
1.17 ± 0.12 |
1.28 ± 0.23 |
|
Phase contrast – Pulmonary artery (n = 106) | ||
| Average velocity (cm/s) |
13.6 ± 6.7 |
7.6 ± 3.4† |
| Retrograde flow (L/min/m2) |
0.2 ± 0.1 |
0.5 ± 0.3† |
| Retrograde flow (%) |
9.3 ± 7.2 |
16.3 ± 9.2† |
| PA relative area change ≥ 15% |
17.8 ± 6.6 |
8.1 ± 6.5† |
| Systolic PA area (cm2) |
7.8 ± 4.6 |
9.7 ± 2.8† |
| Diastolic PA area (cm2) | 6.7 ± 4.7 | 8.9 ± 2.8† |
Mean ± SD values displayed, † tested value significantly different in the PH patient group than in the ‘No PH’ group (p < 0.05).