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. 2012 Aug 14;7(8):e43244. doi: 10.1371/journal.pone.0043244

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© 2012 Girault et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(Vehicle group n = 6, Olanzapine group n = 9). 2a: Glucose evolution before (t = 90 to t = 100) and during (t = 120 to t = 260) ICV Olanzapine infusion (30 µg/kg/h). No significant differences between the 2 groups were detected (ANOVA repeated measures; Time, p<0.001; Time * Group, p = 0.59; Group, p = 0.635). 2b: Endogenous glucose production before (t = 90 to t = 100) and during (t = 120 to t = 260) ICV Olanzapine infusion. No significant changes were detected (ANOVA repeated measures; Time, p = 0.731; Time * Group, p = 0.709; Group, p = 0.84). 2c: Corticosterone levels before (t = 90 to t = 100) and during (t = 120 to t = 260) ICV Olanzapine infusion. No significant changes were detected (ANOVA repeated measures; Time, p = 0.971; Time * Group, p = 0.631; Group, p = 0.546). 2d: Plasma insulin levels before (mean of time points t = 90 and t = 100) and at the end (mean of time points t = 220 and t = 260) of the ICV infusion of Olanzapine. No significant changes were detected (ANOVA repeated measures; Time, p = 0.722; Time * Group, p = 0.638; Group, p = 0.274). Vehicle-treated animals = white dots; Olanzapine-treated animals = black dots.