Table 1. Antiproliferative activity of piperidinylquinoxalines (4–8).

		IC50 (µM)a
Cpd.	2-substituenton quinoxaline	PC3	A549	HCT116	HL60	KB
4	4-carbamoylpiperidin-1-yl	1.20	26.65	1.57	0.22	13.73
5	4-carbamoylpiperidin-1-yl	2.28	27.35	1.20	0.14	11.85
6	4-carbamoylpiperidin-1-yl	2.28	16.97	2.55	0.21	10.23
7	4-carbamoylpiperidin-1-yl	1.17	12.11	1.61	0.15	4.22
8	4-carbamoylpiperidin-1-yl	4.36	10.23	7.13	4.15	6.45
WR1	morpholino	18.88	12.55	5.35	4.47	NTb
LY294002	–	61.35	89.65	56.01	9.94	44.76

^aThe mean value of at least two separate determinations.

^bNT: not tested.