Table 2. Antiproliferative activity of piperazinylquinoxalines (9–13).

		IC50 (µM)a
Cpd.	2-substituenton quinoxaline	PC3	A549	HCT116	HL60	KB
9	4-acetylpiperazin-1-yl	2.25	1.02	1.84	2.43	4.42
10	4-acetylpiperazin-1-yl	2.27	2.42	2.60	3.28	3.89
11	4-acetylpiperazin-1-yl	2.18	18.63	3.66	0.48	10.35
12	4-acetylpiperazin-1-yl	3.03	9.79	0.53	0.12	4.30
13	4-acetylpiperazin-1-yl	3.17	7.12	4.34	1.78	6.15
WR1	morpholino	18.88	12.55	5.35	4.47	NTb
LY294002	–	61.35	89.65	56.01	9.94	44.76

^aThe mean value of at least two separate determinations.

^bNT: not tested.