Table 3. Antiproliferative activity of piperazinylquinoxalines (14–53).

		IC50 (µM)a
Cpd.	2-substituenton quinoxaline	PC3	A549	HCT116	HL60	KB
14	4-methylpiperazin-1-yl	2.94	14.03	2.78	0.77	4.54
15	4-methylpiperazin-1-yl	0.84	2.4	1.68	0.69	0.47
16	4-methylpiperazin-1-yl	1.55	8.57	2.37	0.54	2.53
17	4-methylpiperazin-1-yl	1.01	5.18	2.31	0.28	0.87
18	4-methylpiperazin-1-yl	3.09	7.95	8.21	2.75	21.64
19	piperazin-1-yl	0.90	12.82	0.99	0.11	8.27
20	piperazin-1-yl	1.32	14.39	0.47	0.12	7.26
21	piperazin-1-yl	0.68	1.37	0.63	0.16	11.48
22	piperazin-1-yl	0.36	0.75	0.19	0.10	9.89
23	piperazin-1-yl	2.05	2.79	2.43	1.39	4.58
24	3-methylpiperazin-1-yl	1.44	1.36	0.68	0.15	8.73
25	3-methylpiperazin-1-yl	2.03	1.60	1.17	0.09	9.18
26	3-methylpiperazin-1-yl	0.93	1.65	0.54	0.16	8.53
27	3-methylpiperazin-1-yl	0.60	0.57	0.32	0.12	9.46
28	3-methylpiperazin-1-yl	2.34	3.45	2.20	1.95	2.03
29	4-benzoylpiperazin-1-yl	4.99	5.20	42.36	7.20	1.22
30	4-benzoylpiperazin-1-yl	5.81	8.03	6.90	17.28	3.67
31	4-benzoylpiperazin-1-yl	3.63	7.43	17.24	6.93	5.65
32	4-benzoylpiperazin-1-yl	1.40	3.96	10.08	17.37	3.37
33	4-benzoylpiperazin-1-yl	1.77	1.16	8.88	6.95	1.22
34	4-(4-chlorobenzoyl)piperazin-1-yl	2.74	3.86	25.38	5.84	0.93
35	4-(4-chlorobenzoyl)piperazin-1-yl	3.61	21.57	9.84	6.09	2.84
36	4-(4-chlorobenzoyl)piperazin-1-yl	2.43	>50	9.62	5.58	6.03
37	4-(4-chlorobenzoyl)piperazin-1-yl	2.89	>50	10.57	6.11	5.09
38	4-(4-chlorobenzoyl)piperazin-1-yl	4.05	17.70	8.75	4.44	1.88
39	4-(methylsulfonyl)piperazin-1-yl	1.07	2.37	1.21	NTb	NTb
40	4-(methylsulfonyl)piperazin-1-yl	5.35	1.93	1.07	NTb	NTb
41	4-(methylsulfonyl)piperazin-1-yl	2.21	1.32	0.55	NTb	NTb
42	4-(methylsulfonyl)piperazin-1-yl	1.95	1.32	0.41	NTb	NTb
43	4-(methylsulfonyl)piperazin-1-yl	3.30	1.26	0.33	NTb	NTb
44	4-tosylpiperazin-1-yl	2.19	24.26	7.49	6.40	3.08
45	4-tosylpiperazin-1-yl	3.48	49.47	1.92	9.28	2.68
46	4-tosylpiperazin-1-yl	6.20	>50	14.22	14.95	2.35
47	4-tosylpiperazin-1-yl	4.89	19.51	5.07	10.27	2.73
48	4-tosylpiperazin-1-yl	3.39	48.23	3.76	9.48	5.17
49	4-(3-morpholinopropyl)piperazin-1-yl	5.12	0.73	0.65	NTb	NTb
50	4-(3-morpholinopropyl)piperazin-1-yl	3.83	0.51	0.31	NTb	NTb
51	4-(3-morpholinopropyl)piperazin-1-yl	9.30	2.10	2.59	NTb	NTb
52	4-(3-morpholinopropyl)piperazin-1-yl	1.19	0.34	0.22	NTb	NTb
53	4-(3-morpholinopropyl)piperazin-1-yl	4.80	1.12	0.93	NTb	NTb
LYc	–	61.35	89.65	56.01	9.94	44.76

^aThe mean value of at least two separate determinations.

^bNT: not tested.

^cLY: LY294002.