Table 1. Description of the included studies looking for an association between toxocariasis and epilepsy.
PWE Ascertainment | PWOE | Exposure | ||||||
References | Country | Study design | Sources | Epilepsy definition and classification | Confirmation | Sources | Matching Criteria | Examinations |
Glickman et al., J Pediatr 1979 [30] | USA | Case-control | Pediatric Hospital | Alter et al., 1972 | Cases known by hospital | Outpatients or hospitalized controls | None | Sera Ab-ELISA |
Arpino et al., Epilepsia 1990 [31] | Italy | Case-control | Pediatric Hospital | Not specified (“positive seizure history”) | Cases known by hospital | Pediatric Hospital | None | Sera Ab-ELISA |
Nicoletti et al., Neurology 2002 [35] | Bolivia | Case-control | General population | ILAE 1993; ILAE 1981 | Neurologist | General population | Sex, age ±5 years, same Community | Sera Ab-ELISA, WB |
Akyol et al., Seizure 2007 [41] | Turkey | Case-control | Hospital, consecutively enrolled | Not specified (“idiopathic epilepsy”); ILAE 1981 | Cases known by hospital | Volunteers, source not specified | None | Sera Ab-ELISA |
Nicoletti et al., Epilepsia 2007 [36] | Burundi | Case-control | PWE identified by local health centers | ILAE 1993; ILAE 1981 | Neurologist | Controls coming to hospital for vaccination or PWE neighbors | Age ±5 years, no blood relationship, same province | Sera WB |
Nicoletti et al., Epilepsia 2008 [37] | Italy | Case-control | Epilepsy center, randomly selected | ILAE 1993; ILAE 1981 | Neurologist | Subjects who went to hospital for hematological check, consecutively enrolled | Group-matched by age | Sera WB |
Winkler et al., Trans R Soc Trop Med Hyg. 2008 [38] | Tanzania | Case-control | Hospital, age >10 years | WHO (1993) Winkler et al., 2007 | Neurologist | Subjects who underwent CT for reasons other than seizures | None | Sera Ab-ELISA, WB, CSF Ab-ELISA |
Ab-ELISA, antibodies enzyme-linked immunosorbent assay; CT, computerized tomography; CSF, cerebrospinal fluid; ILAE, International League Against Epilepsy; PWE, people with epilepsy; PWOE, people without epilepsy; WB, Western Blot; WHO, World Health Organization.