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. 2012 Aug 14;6(8):e1775. doi: 10.1371/journal.pntd.0001775

Table 1. Description of the included studies looking for an association between toxocariasis and epilepsy.

PWE Ascertainment PWOE Exposure
References Country Study design Sources Epilepsy definition and classification Confirmation Sources Matching Criteria Examinations
Glickman et al., J Pediatr 1979 [30] USA Case-control Pediatric Hospital Alter et al., 1972 Cases known by hospital Outpatients or hospitalized controls None Sera Ab-ELISA
Arpino et al., Epilepsia 1990 [31] Italy Case-control Pediatric Hospital Not specified (“positive seizure history”) Cases known by hospital Pediatric Hospital None Sera Ab-ELISA
Nicoletti et al., Neurology 2002 [35] Bolivia Case-control General population ILAE 1993; ILAE 1981 Neurologist General population Sex, age ±5 years, same Community Sera Ab-ELISA, WB
Akyol et al., Seizure 2007 [41] Turkey Case-control Hospital, consecutively enrolled Not specified (“idiopathic epilepsy”); ILAE 1981 Cases known by hospital Volunteers, source not specified None Sera Ab-ELISA
Nicoletti et al., Epilepsia 2007 [36] Burundi Case-control PWE identified by local health centers ILAE 1993; ILAE 1981 Neurologist Controls coming to hospital for vaccination or PWE neighbors Age ±5 years, no blood relationship, same province Sera WB
Nicoletti et al., Epilepsia 2008 [37] Italy Case-control Epilepsy center, randomly selected ILAE 1993; ILAE 1981 Neurologist Subjects who went to hospital for hematological check, consecutively enrolled Group-matched by age Sera WB
Winkler et al., Trans R Soc Trop Med Hyg. 2008 [38] Tanzania Case-control Hospital, age >10 years WHO (1993) Winkler et al., 2007 Neurologist Subjects who underwent CT for reasons other than seizures None Sera Ab-ELISA, WB, CSF Ab-ELISA

Ab-ELISA, antibodies enzyme-linked immunosorbent assay; CT, computerized tomography; CSF, cerebrospinal fluid; ILAE, International League Against Epilepsy; PWE, people with epilepsy; PWOE, people without epilepsy; WB, Western Blot; WHO, World Health Organization.