Table 2. Results of the included case-control studies on the association between toxocariasis and epilepsy.
References | PWE, n | PWOE, n | Seropositivity in PWE, n (%) | Seropositivity in PWOE, n (%) | A priori statistical power, %* | A posteriori statistical power, % | OR (95% CI) | p-value |
Glickman et al., J Pediatr 1979 [30] | 84 | 108 | 19 (22.6) | 11 (10.2) | 33.6 | 65.3 | 2.58 (1.15–5.77) | 0.018 |
Arpino et al., Epilepsia 1990 [31] | 91 | 214 | 20 (21.9) | 26 (12.1) | 40.1 | 59.3 | 2.04 (1.07–3.88) | 0.028 |
Nicoletti et al., Neurology 2002 [35] | 113 | 233 | 28 (24.8) | 28 (12.0) | 47.6 | 85.0 | 2.41 (1.35–4.31) | 0.002 |
Akyol et al., Seizure 2007 [41] | 100 | 50 | 12 (12.0) | 4 (8.0) | 32.8 | 11.3 | 1.57 (0.48–5.14) | 0.4 |
Nicoletti et al., Epilepsia 2007 [36] | 191 | 191 | 114 (59.7) | 97 (50.8) | 90.9 | 41.0 | 1.43 (0.96–2.15) | 0.08 |
Nicoletti et al., Epilepsia 2008 [37] | 231 | 201 | 38 (16.4) | 13 (6.5) | 55.8 | 89.6 | 2.85 (1.47–5.51) | 0.001 |
Winkler et al., Trans R Soc Trop Med Hyg. 2008 [38] | 40 | 20 | 19 (47.5) | 8 (40.0) | 33.5 | 8.0 | 1.36 (0.46–4.03) | 0.58 |
Statistical power assuming an odds ratio equal to 2 with a type I error equal to 5% and one control per case.
OR, crude odds ratio; PWE, people with epilepsy as cases; PWOE, people without epilepsy as controls; seropositivity, presence of antibodies anti-Toxocara spp.; 95% CI, 95% confidence interval.