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. 2012 Aug 14;10(8):e1001377. doi: 10.1371/journal.pbio.1001377

Figure 1. Timeline of microbial community studies using high-throughput sequencing.

Figure 1

Each circle represents a high-throughput sequence-based 16S or shotgun metagenomic bioproject in NCBI (May 2012), indicating the amount of sequence data produced for each project (circle area and y-coordinate) at the time of publication/registration (x-coordinate). Projects are grouped by human-associated (red), other animal (black), or environmental (green) communities, and shotgun metagenomic projects are marked with a grey band. Selected representative projects are labeled: open ocean [68], deep sea [69], lean mouse [70], diarrheal illness [71], costal ocean [72], lean/obese gut [53], human microbiome [56], MetaHIT (gut) [58], cow rumen [73], soil (NCBI BioProject PRJNA50473), and human gut [74]. Note that HMP has deposited a total of 7.44 terabases of shotgun data in SRA, of which 49% is host DNA derived data that was filtered and only available through protected access in dbGaP project phs000228.