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. 2012 Aug 14;7(8):e43249. doi: 10.1371/journal.pone.0043249

Table 1. Partial list of genes related to ER stress and autophagy/starvation that are up-regulated in CTet-treated MCF-7 and MDA-MB-231 cells.

Fold change
Accession N. Gene Title Gene ID MCF-7 MDA-MB-231
ER stress-related transcripts CTet 6µM CTet 12µM CTet 6µM CTet 12µM
NM_004024 activating transcription factor 3 ATF3 11.58 30.40 2.45 5.36
NM_133436 asparagine synthetase, transcript variant 1 ASNS 1.85 2.44 1.69 2.66
NM_005980 S100 calcium binding protein P S100P 1.20 2.12 2.11 4.27
NM_019058 DNA-damage-inducible transcript 4 DDIT4 4.91 7.13 3.89 5.71
S62138 TLS/CHOP = hybrid gene (translocation breakpoint) FUS 3.98 8.84 1.84 2.45
NM_024111 ChaC, cation transport regulator homolog 1 (E. coli) CHAC1 4.35 4.86 2.78 3.76
NM_021158 tribbles homolog 3 (Drosophila) TRIB3 1.28 2.07 1.88 2.91
NM_012328 DnaJ (Hsp40) homolog, subfamily B, member 9 DNAJB9 2.67 5.83 2.03 3.32
NM_007034 DnaJ (Hsp40) homolog, subfamily B, member 4 DNAJB4 2.78 4.56 1.93 2.01
NM_006145 DnaJ (Hsp40) homolog, subfamily B, member 1 DNAJB1 1.27 3.08 1.94 2.38
NM_018602 DnaJ (Hsp40) homolog, subfamily A, member 4 DNAJA4 1.30 2.54 1.55 1.85
NM_005346 heat shock 70kDa protein 1B HSPA1B 1.42 2.61 3.99 4.87
NM_005345 heat shock 70kDa protein 1A HSPA1A 1.42 2.49 6.18 6.78
NM_019891 ERO1-like beta (S cerevisiae) ERO1LB 1.97 4.41 2.31 3.43
NM_004235 Kruppel-like factor 4 (gut) KLF4 1.41 2.69 1.34 1.93
NM_172230 HRD1 protein (HRD1), transcript variant 2 SYVN1 1.56 2.42 1.05 1.69
NM_203418 regulator of calcineurin 1 RCAN1 2.68 4.79 2.02 3.16
NM_000584 interleukin 8 IL8 26.93 85.72 3.59 3.34
NM_000600 interleukin 6 (interferon, beta 2) IL6 3.68 12.32 4.92 9.98
NM_000963 prostaglandin-endoperoxide synthase 2 PTGS2 1.00 2.49 20.28 36.65
NM_006096 N-myc downstream regulated gene 1 NDRG1 1.65 2.19 1.30 2.02
NM_005194 CCAAT/enhancer binding protein (C/EBP), beta CEBPB 2.60 5.04 1.63 2.08
NM_000389 cyclin-dependent kinase inhibitor 1A (p21, Cip1) CDKN1A 1.41 2.27 1.72 2.09
NM_000636 superoxide dismutase 2, mitochondrial SOD2 1.43 3.13 1.90 2.77
NM_002133 heme oxygenase (decycling) 1 HMOX1 8.09 15.79 2.75 3.21
NM_182743 thioredoxin reductase 1, transcript variant 4 TXNRD1 3.33 5.34 2.06 2.43
NM_014417 BCL2 binding component 3 BBC3 2.31 4.35 2.87 3.79
Autophagy/starvation-related transcripts
BU942678 sequestosome 1 SQSTM1 1.48 2.31 2.00 2.15
NM_003806 harakiri, BCL2 interacting protein (contains only BH3 domain) HRK 2.05 4.44 1.28 2.83
NM_017983 WD repeat domain, phosphoinositide interacting 1 WIPI1 2.19 4.76 1.58 2.06
NM_021127 phorbol-12-myristate-13-acetate-induced protein 1 PMAIP1 3.56 7.18 1.47 1.86
NM_133436 asparagine synthetase, transcript variant 1 ASNS 1.85 2.44 1.69 2.66
NM_031412 GABA(A) receptor-associated protein like 1 GABARAPL1 3.17 7.30 1.68 2.58
NM_022818 microtubule-associated protein 1 light chain 3 beta MAP1LC3B 2.05 3.77 1.29 1.62
NM_004281 BCL2-associated athanogene 3 BAG3 1.17 2.32 1.51 1.66