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. 2012 Aug 14;7(8):e42454. doi: 10.1371/journal.pone.0042454

Figure 4. TRPA1 mediates IL-8 release by acrolein from human airway/lung cells in primary culture.

Figure 4

Overnight exposure to acrolein (ACR) induces IL-8 release from small airway epithelial cells (SAEC) (A), normal human lung fibroblasts (NHLF) (B) and human bronchial smooth muscle cells (HBSMC) (C) in a concentration–dependent manner. IL-8 release evoked by ACR is reduced by HC-030031 (HC, 30 µM) and AP18 (10 µM). Each column represents mean ± SEM of at least 3 independent experiments. § P<0.05 vs. Basal group or Veh/Veh-ACR; * P<0.05 vs. Veh/ACR.