Table 2. Geometric mean IgG pneumococcal antibody concentrations to individual polysaccharides at baseline and the proportion of participants with concentrations above threshold concentrations.
30 months – 4 years | 5 years+ | |||||||||||
Control Villages | Vaccinated villages | Control Villages | Vaccinated villages | |||||||||
Serotypes | GM | % ≥0.35µg/ml | % >5.0µg/ml | GM | % ≥0.35µg/ml | % >5.0µg/ml | GM | % ≥0.35µg/ml | % >5.0µg/ml | GM | % ≥0.35µg/ml | % >5.0µg/ml |
PCV-7 | ||||||||||||
4 | 0.42 | 51.7 | 3.3 | 0.24 | 50.9 | 2.8 | 0.5 | 75.8 | 5.8 | 0.73 | 78.3 | 11.2 |
6B | 0.36 | 60 | 3.3 | 0.3 | 63 | 11.1 | 0.95 | 79.5 | 12.7 | 1.53 | 96.1 | 12.8 |
9V | 0.54 | 65 | 0 | 0.84 | 71.3 | 11.1 | 1.42 | 92 | 6 | 2.14 | 96 | 23 |
14 | 0.51 | 53.3 | 5 | 0.85 | 70.4 | 11.1 | 2.27 | 80.5 | 38.2 | 2.26 | 93.6 | 29.7 |
18C | 0.21 | 45 | 3.3 | 0.26 | 49.1 | 14.8 | 0.62 | 73.2 | 1.7 | 1.13 | 85.9 | 13.6 |
19F | 0.87 | 75 | 21.7 | 1.2 | 85.2 | 25 | 2.24 | 91.2 | 23.7 | 2.47 | 94.4 | 29.6 |
23F | 0.15 | 40 | 3.3 | 0.26 | 50 | 13.9 | 0.6 | 73.2 | 11.3 | 0.88 | 73.7 | 16.3 |
Non-PCV-7 | ||||||||||||
1 | 0.18 | 28.3 | 0 | 0.22 | 35.2 | 0 | 0.6 | 70.2 | 5.5 | 0.79 | 72.3 | 16.9 |
3 | 0.71 | 51.7 | 25 | 0.58 | 54.6 | 18.5 | 0.63 | 65 | 13.5 | 0.49 | 49.2 | 10.2 |
5 | 0.37 | 58.3 | 6.7 | 0.4 | 61.1 | 11.1 | 0.95 | 87.7 | 7.8 | 1.73 | 94.5 | 18.3 |
12F | 0.31 | 38.3 | 0 | 0.43 | 43.5 | 6.5 | 0.64 | 65 | 6.7 | 1.13 | 78.1 | 12.1 |
At baseline the vaccinated and control communities were combined, and analysed according to those between 30 months and 4 years of age and those 5 years and above. The geometric means (GM) of the antibody concentrations, the proportions with concentrations that are postulated to protect against invasive pneumococcal disease (≥0.35 mg/ml) and nasopharyngeal carriage (≥5.0 µg/ml) are shown.