Annual change in MMSE scores during the 8 years between examinations 20 (baseline) and 24 of the Framingham Original Cohort (n = 549) for users and non-users of supplements containing folic acid, stratified by vitamin B-12 status. Results are controlled for age, sex, educational achievement, and baseline status for serum creatinine, BMI, and smoking status. Points represent β-coefficients. Error bars represent 95% CI for the β-coefficients. Subgroups indicated by the same letter do not differ significantly.