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. Author manuscript; available in PMC: 2013 Aug 21.
Published in final edited form as: Acc Chem Res. 2012 Apr 23;45(8):1237–1246. doi: 10.1021/ar200303k

Figure 5.

Figure 5

Stabilizing effect of C-H…F interactions in FANA-modified DNAs. (A) Tight contact between FANA-T 2′-fluorine and C8-H of dA at a (faT)p(dA) Py-Pu step in an A-form duplex (PDB code 2FIL).41 (B) Incorporation of FANA residues (capital font in blue) into an oligo-2′-deoxynucleotide (small font) at Py-Pu steps leads to increased stability of the duplex with complementary RNA (UV melting assay) compared to a mixed FANA-DNA strand of identical composition but lacking a Py-Pu step.42