Table 4.
Behavioral correlates of alcohol cue-elicited brain activation
| Behavioral measure | First author, year | N | Midbrain/limbic | Prefrontal | Motor | Par | Temp | Occ | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| VTA | Thal | DS | VS | Amg | Ins | ACC | PCC | OFC | vmPFC | latPFC | |||||||
| ADS | Claus, 2011 | 326 | L, R | R | L | L | L | L | L | L | |||||||
| AUDIT | Filbey, 2008 | 37 | L, R | L, R | L, R | M | L, R | M | |||||||||
| Claus, 2011 | 326 | L | R | R | L | L | |||||||||||
| AUQ | Filbey, 2008 | 37 | R | M | |||||||||||||
| DAQ | |||||||||||||||||
| -Mild desires to drink | Tapert, 2003 | 15 | La | L | R | R | L, R | ||||||||||
| -Strong desires and intentions to drink | Tapert, 2003 | 15 | R | ||||||||||||||
| Tapert, 2004 | 8 | L | |||||||||||||||
| -Reinforcing effects | Tapert, 2003 | 15 | Ra | Ra | |||||||||||||
| Tapert, 2004 | 8 | L | |||||||||||||||
| ICSFC | Claus, 2011 | 326 | L | L, R | R | L | L, R | L, R | |||||||||
| OCDS | Wrase, 2007 | 13 | R | ||||||||||||||
| Vollstädt-Klein, 2010 | 31 | R | Lb | ||||||||||||||
| In-scanner craving | Modell, 1995 | 9 | R | ||||||||||||||
| Myrick, 2004 | 10 | L | L | L | |||||||||||||
| Park, 2007 | 9 | L, R | L | L, R | L, R | L, R | |||||||||||
| Filbey, 2008 | 37 | R | |||||||||||||||
| Myrick, 2008 | 107 | R | |||||||||||||||
| Drinking | |||||||||||||||||
| -Drinks per month | Tapert, 2003 | 15 | R | L | L, R | ||||||||||||
| -Alcohol intake after scan | Grüsser, 2004 | 10 | M | ||||||||||||||
| -Heavy drinking days | Bragulat, 2008 | 9 | L | ||||||||||||||
| -While on 15mg APZ | Myrick, 2010 | 14 | R | ||||||||||||||
| -Years regular drinking | Claus, 2011 | 326 | L | L, R | L, R | ||||||||||||
Results from ROI analyses are bolded.
a
Negative correlation;
b
Negative correlation among heavy drinkers (N = 21) only;
c
Among male participants (N = 20) only.
Abbreviations: VTA = ventral tegmental area; Thal = thalamus; DS = dorsal striatum; VS = ventral striatum; Amg = amygdala; Ins = insula; ACC = anterior cingulate; PCC = posterior cingulate; OFC = orbitofrontal cortex; vmPFC = ventromedial prefrontal; latPFC = lateral prefrontal; Motor = pre-, post-central gyri, cerebellum; Par = parietal; Temp = temporal; Occ = occipital; APZ = aripiprazole.