Skip to main content
. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Int J Lab Hematol. 2012 May 10;34(5):473–483. doi: 10.1111/j.1751-553X.2012.01420.x

Table 3.

Significant SNPs associated with platelet reactivity defined by reference cut-off points in Caucasian patients (N=423) based on FDR<0.15

a. SNPs associated with high residual platelet activity
Platelet Reactivity* Gene rs SNP ID Genotype† n (%) p-value‡ (FDR)§ Odds Ratio (95% CI)
AA-and ADP-stimulated aggregation (%) <20 and/or <70 ≥20 and ≥70
0.5 mg/mL AA and 10 μM ADP, maximum P2RY12 rs9859538 A/A
G/A+G/G		 110 (35)
203 (65)		 22 (22)
77 (78)		 0.004 (0.156) 2.16 (1.24, 3.75)
b. SNPs associated with moderate residual platelet activity
Platelet Reactivity* Gene rs SNP ID Genotype† n (%) p-value‡ (FDR)§ Odds Ratio (95% CI)
ADP-stimulated Aggregation (%) <70 ≥70
5 μM ADP, 10 minutes P2RY12 rs1491974 C/C
T/C+T/T		 105 (30)
249 (70)		 9 (15.5)
49 (84.5)		 0.004 (0.133) 2.94 (1.33, 6.51)
rs10513398 G/G
A/G+A/A		 104 (29)
254 (71)		 9 (15.5)
49 (84.5)		 0.008 (0.133) 2.69 (1.23, 5.88)
10 μM ADP, maximum P2RY12 rs3732765 G/G
A/G+A/A		 36 (49)
37 (51)		 124 (36)
219 (64)		 0.028 (0.138) 1.79 (1.07, 3.00)
rs10935841 G/G
A/G+A/A		 36 (49)
37 (51)		 124 (36)
220 (64)		 0.026 (0.138) 1.80 (1.07, 3.01)
c. SNPs associated with low residual platelet reactivity
Platelet Reactivity* Gene rs SNP ID Genotype† n (%) p-value‡ (FDR)§ Odds Ratio (95% CI)
ADP-stimulated Aggregation (%) <70 ≥ 70
10 μM ADP, maximum P2RY12 rs7615865 C/C
T/C+T/T		 24 (34)
47 (66)		 164 (48.4)
175 (51.6)		 0.019 (0.138) 0.53 (0.31, 0.91)
rs1388623 C/C
A/C+A/A		 26 (35.6)
47 (64.4)		 179 (52)
165 (48)		 0.008 (0.138) 0.50 (0.29, 0.84)
rs1388622 G/G
A/G+A/A		 26 (35.6)
47 (64.4)		 179 (52)
165 (48)		 0.008 (0.138) 0.50 (0.29, 0.84)
rs7634096 G/G
A/G+A/A		 40 (55)
33 (45)		 234 (68)
110 (32)		 0.026 (0.138) 0.55 (0.33, 0.93)
rs7637803 G/G
A/G+A/A		 40 (55)
33 (45)		 234 (68)
110 (32)		 0.026 (0.138) 0.55 (0.33, 0.93)
TxB2 (ng/mL) <1 ≥1
P2RY1 rs1439010 T/T
C/T+C/C		 200 (70)
86 (30)		 67 (82)
15(18)		 0.035 (0.114) 0.53 (0.28, 0.99)
rs1371097 C/C
T/C+T/T		 199 (70)
86 (30)		 66 (81.5)
15 (18.5)		 0.039 (0.114) 0.54 (0.29, 1.01)
rs701265 A/A
G/A+G/G		 200 (70)
87 (30)		 67 (82)
15 (18)		 0.031 (0.114) 0.52 (0.28, 0.97)
rs12497578 C/C
G/C+G/G		 220 (77)
66 (23)		 74 (90)
8 (10)		 0.003 (0.067) 0.36 (0.16, 0.79)
rs2312265 A/A
G/A+G/G		 200 (70)
87 (30)		 67 (82)
15 (18)		 0.031 (0.114) 0.52 (0.28, 0.97)

FDR, false discovery rate; CI, confidence interval; ADP, adenosine diphosphate; TxB2, thromboxane B2.

*

Only assays of platelet reactivity with significant associations are shown.

†

Wild type genotype is shown in bold.

‡

P-values were obtained by logistic regression analysis adjusted by gender, age, and smoking.

§

Associations are based on FDR<0.15 except the one in Table 3a which is 0.156.