Table 1.
Baseline characteristics of subjects with thalassemia, including anthropometrics, genotype, transfusion history and total body iron stores
| Total | Young Children | Older Children & Adolescents |
Adults | p-value2 | |
|---|---|---|---|---|---|
| Number of Subjects | 221 | 30 | 83 | 108 | - |
| Age, years 1 | 19.7±11.3 | 5.4 ±1.4 | 12.6±3.3 | 29.0 ±8.3 | - |
| Gender, % male | 48.0% | 40.0% | 54.2% | 45.4% | 0.31 |
| Race, % | Asian, 51.6% Caucasian, 43.4% Other, 5.0% | Asian, 80.0% Caucasian, 13.3% Other, 6.7% | Asian, 53.0% Caucasian, 38.6% Other, 8.4 % | Asian, 42.6% Caucasian, 55.6% Other, 1.9% | <0.0001 |
| Body Mass Index, kg/m2 | 20.3±4.5 | 15.9±2.7 | 18.3±4.1 | 22.9 ±3.3 | - |
| Thalassemia Genotype,3 % of sample | β-thalassemia, 78.8% E- β Thal, 13.8% Hb H/CS, 4.6% Other, 2.8% | β-thalassemia, 73.3% E- β Thal, 10.0% Hb H/CS, 13.3% Other, 3.3% | β-thalassemia, 80.5% E- β Thal, 8.5% Hb H/CS, 6.0% Other, 5.0% | β-thalassemia, 79.0% E- β Thal, 19.0% Hb H/CS, 1.0% Other, 1.0% | 0.01 |
| Chronically transfused, % of sample | 90.0% | 96.0% | 94.5% | 85.4% | 0.09 |
| Years on chronic transfusion therapy | 16.5±11.0 | 3.8±1.7 | 10.5±4.0 | 24.7±9.6 | <0.0001 |
| Serum ferritin, ng/mL (range) 4,5 | 1236 (85 to 14,835) {n=216} | 921 (89 to 3218) {n=29} | 1136 (85 to 9480) {n=82} | 1441 (129 to 14,835) {n=105} | 0.004 |
| Liver Iron Concentration, 6 mg/kg (range) | 9.6 (1.0 – 42.9) {n=195} | 9.4 (3.0 – 21.3) {n=23} | 9.3 (1.1 – 42.9) {n=75} | 10.0 (1.0 – 40.0) {n=97} | <0.0001 |
1
Values are presented as Mean±SD (range)
2
For continuous variables, p-values are from ANOVA, for categorical variables, p-values are from Fisher’s Exact test.
3
Thalassemia Genotype: E-B Thal: E-beta thalassemia, HbH/CS: Hemoglobin H/constant spring
4
Where numbers of subjects are different than the group as a whole, sample size is included in {}.
5
Due to skewness of the data, serum ferritin and liver iron concentration are presented as Median (range) and all analyses are performed in log scale
6
Liver iron concentration: determined from either magnetic resonance imaging, liver biopsy or Ferritometer.