Skip to main content
. 2012 Jul 25;32(30):10201–10210. doi: 10.1523/JNEUROSCI.1496-12.2012

Figure 4.

Figure 4.

Chronic MW-151 administration prevents synaptic loss. Neocortex tissue was analyzed for the levels of synaptic proteins by Western blots. Compared to WT mice treated with vehicle (veh; white bars), the APP/PS1 mice treated with vehicle (gray bars) show reduced levels of the synaptic proteins PSD95 (A), synaptophysin (B), syntaxin (C), and SNAP25 (D). MW-151 treatment of the APP/PS1 mice protected against this loss of synaptic protein levels, restoring the levels back toward WT values. *p < 0.05 compared to vehicle-treated APP/PS1 mice.