Figure 5.

Effects of short-term MW-151 treatment in acute intervention paradigm. Eleven-month-old mice were treated with either saline vehicle (veh; white bars, WT; gray bars, APP/PS1) or with 2.5 mg/kg/d MW-151 i.p. (black bars, APP/PS) once daily for 1 week. Neocortex tissue was harvested and endpoints were measured. A, Short-term MW-151 treatment reduced the levels of IL-1β, but not IL-10, and had no effect on microglial (IBA1) or astrocyte (GFAP) activation. B, MW-151 treatment prevented the loss of PSD95 and synaptophysin, but the protection against syntaxin and SNAP25 loss did not reach significance. *p < 0.05 compared to vehicle-treated APP/PS1 mice.