Table 1.
Selective effects of MW-151 on inflammation-related gene expression markers
| Δ > 20% | p < 0.05 (*) | Vehicle | MW-151 | Gene/TaqMan assay ID | |
|---|---|---|---|---|---|
| IBA1 | ↓ | * | 100 ± 9 | 75 ± 4 | Aif1/Mm00479862_g1 |
| CD45 | 100 ± 8 | 88 ± 10 | Ptprc/Mm01293575_m1 | ||
| CD68 | ↓ | * | 100 ± 9 | 74 ± 2 | Cd68/Mm00839636_g1 |
| TLR2 | 100 ± 13 | 118 ± 17 | Tlr2/Mm00442346_m1 | ||
| TLR4 | ↑ | 100 ± 15 | 150 ± 34 | Tlr4/Mm00445273_m1 | |
| NOS2 | 100 ± 15 | 113 ± 18 | Nos2/Mm00440502_m1 | ||
| TNFα | ↓ | 100 ± 12 | 62 ± 18 | Tnf/Mm00443258_m1 | |
| TGFβ | ↓ | * | 100 ± 7 | 75 ± 3 | Tgfb1/Mm00441726_m1 |
| IGF1 | ↓ | 100 ± 28 | 76 ± 17 | Igf1/Mm00439561_m1 | |
| CD200 | ↑ | * | 100 ± 9 | 218 ± 57 | Cd200/Mm00487740_m1 |
| Fractalkine | ↑ | * | 100 ± 9 | 134 ± 6 | Cx3cl1/Mm00436454_m1 |
| HMGB1 | ↓ | * | 100 ± 9 | 70 ± 3 | Hmgb1/Mm00849805_gH |