Table 1. Overview of optimal solution space characterizations with CoPE-FBA for eight different genome-scale metabolic network models¹¹,³⁹,¹²,¹⁶,²⁵,²⁹ for growth on various carbon sources. The calculations in this table were obtained from our CoPE-FBA method described in the Supplementary Information. Unpublished L. lactis, S. thermophilus, L. bulgaricus reconstructions were provided by Prof. B. Teusink (VU University, Amsterdam).

	reactions	C-source	vertices	rays	lin. sp. columns	modules	reactions in modules	zero fluxes	fixed nonzero fluxes	variable fluxes
M. barkeri	688	methanol	512	5	5	7	34	294	338	56
E. coli iJR904	1066	glucose	17280	8	1	5	59	716	271	79
E. coli iJR904	1066	threonine	1152	8	1	7	34	728	283	55
E. coli iJR904	1066	arginine	2304	8	1	7	39	750	277	59
E. coli iJR904	1066	citrate	1920	8	1	8	42	749	275	62
E. coli iJR904	1066	fumarate	640	8	1	8	37	752	277	57
E. coli iJR904	1066	glutamine	1920	8	1	7	40	750	276	60
E. coli iJR904	1066	lactose	17280	8	1	5	59	728	279	79
E. coli iJR904	1066	malate	320	8	1	7	34	753	279	54
E. coli iJR904	1066	tryptophane	1728	8	1	4	48	743	275	68
M. tuberculosis	1020	glycerol	1327104	7	11	12	96	542	347	131
L. bulgaricus	474	lactose	2240	35	1	1	122	160	179	135
L. lactis	735	glucose	192	1	11	7	33	354	337	53
S. thermophilus	555	lactose	96	2	1	5	50	239	259	57
S. PC6803	331	glycerol	384	4	2	4	32	123	162	46
E. coli iAF1260	2374	glucose	1679616	25	1	4	118	1900	324	150
E. coli iAF1260	2374	threonine	5038848	25	1	7	76	1899	364	111