Table II.
Trajectories of regional brain volume changes in the obese and nonobese (categorical analysis) and across the range of bmi or waist circumference values (continuous analysis)
| Outcomes | Categorical analysis | Continuous analysis | ||||||
|---|---|---|---|---|---|---|---|---|
| Nondemented only | Whole sample | Nondemented only | Whole sample | |||||
| Age X global obesity (SE) | Age X central obesity (SE) | Age X global obesity (SE) | Age X central obesity (SE) | Age X BMI | Age X WC | Age X BMI | Age X WC | |
| General | ||||||||
| Whole brain | 0.48 (0.95) | 0.13 (0.53) | −1.28 (0.92) | −0.67 (0.53) | −0.02 (0.07) | −0.03* (0.02) | −0.11 (0.06) | −0.05* (0.02) |
| vCSF | 0.03 (0.30) | −0.19 (0.18) | 0.18 (0.29) | −0.20 (0.17) | −0.02 (0.02) | −0.00 (0.06) | −0.01 (0.02) | 0.003 (0.01) |
| WM | 0.93 (0.81) | 0.24 (0.44) | 0.20 (0.20) | −0.31 (0.46) | 0.04 (0.06) | −0.02 (0.01) | −0.03 (0.06) | −0.03* (0.01) |
| GM | −0.44 (0.73) | −0.19 (0.41) | −1.65* (0.77) | −0.49 (0.45) | −0.09 (0.05) | −0.02 (0.01) | −0.11 (0.05) | −0.02 (0.02) |
| WM | ||||||||
| Frontal | 0.15 (0.34) | −0.06 (0.19) | −0.09 (0.33) | −0.23 (0.18) | 0.01 (0.02) | −0.01* (0.01) | −0.02 (0.02) | −0.02* (0.01) |
| Temporal | 0.36 (0.27) | −0.07 (0.15) | 0.07 (0.27) | −0.23 (0.15) | −0.01 (0.02) | −0.02*** (0.004) | −0.03 (0.02) | −0.02*** (0.01) |
| Parietal | 0.19 (0.20) | 0.09 (0.11) | 0.28 (0.19) | 0.04 (0.10) | 0.02 (0.01) | 0.004 (0.003) | 0.01 (0.01) | 0.004 (0.003) |
| Occipital | 0.20 (0.18) | 0.04 (0.09) | 0.07 (0.17) | −0.01 (0.09) | 0.01 (0.01) | −0.004 (0.003) | −0.002 (0.01) | −0.01* (0.003) |
| GM | ||||||||
| Frontal | −0.36 (0.29) | −0.11 (0.15) | −0.86* (0.28) | −0.28 (0.16) | −0.03 (0.02) | −0.005 (0.01) | −0.02 (0.02) | −0.01 (0.01) |
| Temporal | −0.28 (0.21) | 0.11 (0.12) | −0.64* (0.23) | −0.05 (0.13) | 0.01 (0.02) | 0.001 (0.004) | −0.02 (0.02) | −0.002 (0.01) |
| Parietal | 0.03 (0.19) | 0.06 (0.10) | −0.32 (0.22) | −0.06 (0.12) | −0.01 (0.01) | −0.003 (0.003) | −0.01 (0.02) | −0.002 (0.004) |
| Occipital | 0.07 (0.15) | −0.02 (0.08) | 0.08 (0.15) | −0.03 (0.08) | −0.01 (0.01) | −0.001 (0.002) | −0.001 (0.01) | 0.003 (0.003) |
| Other | ||||||||
| Orbito‐frontal | 0.04 (0.06) | 0.00 (0.03) | −0.15* (0.07) | −0.04 (0.04) | 0.00 (0.00) | 0.002 (0.001) | −0.001 (0.01) | −0.000 (0.001) |
| Cingulate | −0.03 (0.07) | 0.01 (0.04) | −0.20* (0.07) | −0.05 (0.04) | −0.01 (0.00) | −0.001 (0.001) | −0.01* (0.01) | −0.003* (0.001) |
| Hippocampus | 0.02 (0.01) | 0.00 (0.01) | 0.01 (0.01) | 0.00 (0.01) | 0.01 (0.01) | 0.00 0.00 | 0.001 (0.001) | −0.0002 (0.0003) |
| Precuneus | −0.01 (0.02) | 0.01 (0.01) | −0.11*** (0.03) | −0.02 (0.01) | 0.00, 0.00 | −0.001, 0.003 | −0.003, 0.002 | −0.001, (0.001) |
Abbreviations: WM = white matter; GM = gray matter; vCSF = ventricular cerebro‐spinal fluid; SE = standard error.
***
***P ≤ 0.003 (Bonferroni adjusted);
*
P ≤ 0.05.