Table 1.
Baseline characteristics.
| Variable | n (%) | Mean (SD) |
|---|---|---|
| Age (years; N = 2822) | 46.4 (10.0) | |
| Gender: female (N = 2824) | 2050 (72.6) | |
| Currently unable to work a (N = 2825) | 1266 (44.8) | |
| Duration of inability to work in the last 12 months (weeks; N = 2732) | 7.8 (13.5) | |
| Age at onset of depression (years; N = 2779) | 37.2 (11.7) | |
| Time since onset of depression (years; N = 2777) | 9.2 (9.4) | |
| Any hospitalization during the last 12 months (N = 2802) | 316 (11.2) | |
| Any suicide attempt during the last 12 months (N = 2793) | 74 (2.6) | |
| Duloxetine starting dose (N = 2816) | ||
| 30 mg | 2051 (72.6) | |
| 60 mg | 756 (26.8) | |
| Reason to start or change to duloxetine (N = 2825) | ||
| Inadequate efficacy of pretreatment | 1365 (48.3) | |
| Initial treatment | 1350 (47.8) | |
| Patient decision | 412 (14.6) | |
| Inadequate tolerability of pretreatment | 314 (11.1) | |
| History of antidepressant therapy in the last week (N = 2825) yes | 1611 (57.0) | |
| No antidepressant therapy | 1214 (43.0) | |
| Single antidepressant treatment | 1219 (43.2) | |
| Most common (>2% of patients) single antidepressant therapies: | ||
| Tricyclic antidepressant | 515 (18.2) | |
| Selective serotonin reuptake inhibitor | 410 (14.5) | |
| Noradrenergic and specific serotonergic antidepressant | 126 (4.5) | |
| Selective serotonin and noradrenaline reuptake inhibitor | 74 (2.6) | |
| Multiple antidepressant treatment | 392 (13.9) | |
| Patients with overall pain VAS >30 mm | 2185 (79.4) | |
| Any permanent pain medication (N = 2813) | 769 (27.2) | |
| Any on demand pain medication in the last 12 months (N = 2801) | 1744 (61.7) | |
| Any concomitant somatic diseases (N = 2825) | 1813 (64.2) | |
| Most common (>9% of patients) concomitant somatic diseases:b | ||
| Muscle and skeleton diseases | 871 (30.8) | |
| Hypertension | 573 (20.3) | |
| Allergies | 306 (10.8) | |
| Metabolic diseases | 277 (9.8) | |
| Gastrointestinal diseases | 275 (9.7) | |
| Neurologic diseases | 261 (9.2) |
N: number of patients with available data; n: number of patients in category; SD: standard deviation.
aAnswer “yes” to the question “Is the patient unable to work today?”.
bAs selected from the check list.