Table 2.
Associations between intensity-weighted lifetime days of pesticide use and prostate cancer risk by lipid metabolism variants where FDR P interaction <0.21.
| Pesticide | Gene | SNP | SNP region | Genotype | Nonexposed | Low exposed | High exposed | Exposure trend | P interaction2 | FDR P interaction1,2 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Case/control | Case/control | OR2 | (95% CI)2 | P 2 | Case/control | OR2 | (95% CI)2 | P 2 | OR2 | (95% CI)2 | P 2 | ||||||||
|
ALOXE3
(epidermis-type lipoxygenase 3) |
rs3027208 | IVS7+369G>A | CC CT+TT |
307/576 99/227 |
REF REF |
102/195 43/55 |
0.99 1.86 |
(0.74–1.31) (1.16–2.99) |
0.93 0.01 |
81/188 50/60 |
0.81 2.00 |
(0.60–1.10) (1.28–3.15) |
0.18 0.00 |
0.91 1.45 |
(0.79–1.05) (1.16–1.81) |
0.22 0.001 |
0.001 | 0.08 | |
| Terbufos |
SEC14L2
(SEC14-like protein 2) |
rs2072159 | IVS2−93G>A | GG AG+AA |
201/457 204/342 |
REF REF |
83/139 61/108 |
1.38 0.97 |
(0.99–1.92) (0.67–1.40) |
0.05 0.88 |
82/132 47/115 |
1.43 0.70 |
(1.03–1.99) (0.48–1.03) |
0.03 0.07 |
1.21 0.86 |
(1.03–1.42) (0.71–1.03) |
0.02 0.10 |
0.003 | 0.15 |
|
ADIPOR1
(adiponectin receptor 1) |
rsl2733285 | IVS1−1748G>A | CC CT+TT |
183/421 223/372 |
REF REF |
74/123 70/126 |
1.39 0.96 |
(0.98–1.96) (0.68–1.35) |
0.07 0.80 |
80/131 51/117 |
1.43 0.75 |
(1.02–1.99) (0.52–1.10) |
0.04 0.14 |
1.21 0.88 |
(1.03–1.43) (0.74–1.05) |
0.02 0.16 |
0.01 | 0.18 | |
1Accounts for 220 SNPs included in interaction analyses.
2Risk estimates adjusted for age and state.