Table 3.
Associations between intensity-weighted lifetime days of pesticide use and prostate cancer risk by lipid metabolism variants where FDR P interaction <0.051.
| Pesticide | Gene | SNP | SNP region | Genotype | Non-exposed | Low exposed | High exposed | Exposure trend | P interaction2 | FDR P interaction1,2 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Case/control | Case/control | OR2 | (95% CI)2 | P 2 | Case/control | OR2 | (95% CI)22 | P 2 | OR2 | (95% CI)2 | P 2 | |||||||||
| Insecticides | ||||||||||||||||||||
|
| ||||||||||||||||||||
| Terbufos |
ALOXE3
(epidermis-type lip oxygenase 3) |
rs3027208 | IVS7+369G>A | CC CT+TT |
307/576 99/227 |
REF REF |
102/195 43/55 |
0.99 1.86 |
(0.74–1.31) (1.16–2.99) |
0.93 0.01 |
81/188 50/60 |
0.81 2.00 |
(0.60–1.10) (1.28–3.15) |
0.18 0.00 |
0.91 1.45 |
(0.79–1.05) (1.16–1.81) |
0.22 0.001 |
0.001 | 0.01 | |
|
SEC14L2
(SEC14-like protein 2) |
rs2072159 | IVS2−93G>A | GG AG+AA |
201/457 204/342 |
REF REF |
83/139 61/108 |
1.38 0.97 |
(0.99–1.92) (0.67–1.40) |
0.05 0.88 |
82/132 47/115 |
1.43 0.70 |
(1.03–1.99) (0.48–1.03) |
0.03 0.07 |
1.21 0.86 |
(1.03–1.42) (0.71–1.03) |
0.02 0.10 |
0.003 | 0.01 | ||
|
ADIPOR1
(adiponectin receptor 1) |
rs12733285 | IVS1−1748G>A | CC CT+TT |
183/421 223/372 |
REF REF |
74/123 70/126 |
1.39 0.96 |
(0.98–1.96) (0.68–1.35) |
0.07 0.80 |
80/131 51/117 |
1.43 0.75 |
(1.02–1.99) (0.52–1.10) |
0.04 0.14 |
1.21 0.88 |
(1.03–1.43) (0.74–1.05) |
0.02 0.16 |
0.01 | 0.02 | ||
|
| ||||||||||||||||||||
| Fonofos |
ABCG8
(ATP-binding cassette subfamily G member 8) |
rs4953028 | IVS10+205G>A | GG AG+AA |
141/345 368/644 |
REF REF |
26/38 59/120 |
1.73 0.89 |
(0.99–3.00) (0.63–1.25) |
0.05 0.50 |
36/46 56/106 |
1.94 0.95 |
(1.17–3.20) (0.66–1.36) |
0.01 0.77 |
1.43 0.96 |
(1.12–1.82) (0.81–1.14) |
0.004 0.63 |
0.005 | 0.02 | |
|
| ||||||||||||||||||||
| Carbofuran |
A4GALT
(lactosylceramide 4-alpha-galactosyltransferase) |
rs8136914 | IVS1+4129T>C | AA AG+GG |
210/477 222/378 |
REF REF |
69/128 54/93 |
1.22 1.01 |
(0.87–1.71) (0.69–1.47) |
0.25 0.96 |
72/115 48/107 |
1.43 0.76 |
(1.02–2.00) (0.52–1.12) |
0.04 0.17 |
1.20 0.89 |
(1.02–1.41) (0.75–1.07) |
0.03 0.22 |
0.02 | 0.03 | |
|
LDLR
(low-density lipoprotein receptor) |
rs8110695 | IVS1−4369T>A | TT AT+AA |
285/509 145/342 |
REF REF |
76/132 47/92 |
1.04 1.17 |
(0.75–1.43) (0.78–1.76) |
0.82 0.44 |
64/138 55/83 |
0.83 1.58 |
(0.60–1.16) (1.06–2.33) |
0.27 0.02 |
0.93 1.24 |
(0.80–1.09) (1.03–1.51) |
0.36 0.02 |
0.02 | 0.04 | ||
|
| ||||||||||||||||||||
| Herbicides | ||||||||||||||||||||
|
| ||||||||||||||||||||
| EPTC |
ALOX15
(arachidonate 15-lipoxygenase) |
rs916055 | Ex14+241T>C | AA AG+GG |
242/433 274/592 |
REF REF |
34/45 45/70 |
1.38 1.47 |
(0.85–2.23) (0.98–2.22) |
0.19 0.06 |
18/58 42/58 |
0.56 1.63 |
(0.32–0.99) (1.06–2.50) |
0.05 0.02 |
0.85 1.31 |
(0.67–1.09) (1.07–1.60) |
0.19 0.01 |
0.01 | 0.01 | |
|
| ||||||||||||||||||||
| Petroleum iil/distillates |
ALOX5
(arachidonate 5-lipoxygenase) |
rs7099684 | IVS12−61T>C | TT AT+AA |
281/602 200/346 |
REF REF |
33/63 19/36 |
1.19 0.91 |
(0.76–1.86) (0.51–1.63) |
0.45 0.76 |
43/60 14/41 |
1.56 0.60 |
(1.03–2.38) (0.32–1.13) |
0.04 0.12 |
1.24 0.80 |
(1.02–1.51) (0.60–1.07) |
0.03 0.13 |
0.02 | 0.02 | |
|
LRP1
(low-density lipoprotein receptor-related protein 1) |
rs1800159 | IVS62+86A>G | GG AG+AA |
229/477 258/484 |
REF REF |
18/51 34/52 |
0.74 1.26 |
(0.42–1.31) (0.80–2.00) |
0.31 0.32 |
20/58 41/45 |
0.72 1.76 |
(0.42–1.23) (1.12–2.77) |
0.23 0.01 |
0.83 1.32 |
(0.65–1.07) (1.07–1.63) |
0.15 0.01 |
0.01 | 0.03 | ||
| rs7956957 | IVS78−51C>G | GG CG+CC |
209/417 279/547 |
REF REF |
14/44 38/59 |
0.66 1.32 |
(0.35–1.23) (0.85–2.03) |
0.19 0.22 |
17/46 44/57 |
0.75 1.57 |
(0.42–1.34) (1.03–2.40) |
0.33 0.04 |
0.83 1.26 |
(0.63–1.09) (1.04–1.54) |
0.17 0.02 |
0.02 | 0.03 | |||
| rs6581128 | IVS42−916C>A | CC AC+AA |
227/452 261/509 |
REF REF |
21/49 31/54 |
0.87 1.17 |
(0.51–1.49) (0.73–1.87) |
0.61 0.52 |
18/51 43/50 |
0.70 1.73 |
(0.40–1.23) (1.12–2.68) |
0.22 0.01 |
0.84 1.29 |
(0.65–1.09) (1.05–1.59) |
0.20 0.01 |
0.02 | 0.03 | |||
| rs7978567 | IVS67−220C>T | CC CT+TT |
219/437 268/527 |
REF REF |
16/48 36/55 |
0.69 1.34 |
(0.38–1.25) (0.86–2.10) |
0.22 0.20 |
20/49 41/54 |
0.83 1.56 |
(0.48–1.43) (1.01–2.41) |
0.49 0.05 |
0.87 1.26 |
(0.67–1.13) (1.03–1.55) |
0.29 0.02 |
0.03 | 0.04 | |||
|
ACSL5
(acyl-CoA synthetase long hain) |
rs12098576 | IVS6−530C>A | GG GT+TT |
379/715 109/249 |
REF REF |
35/71 17/32 |
0.96 1.20 |
(0.63–1.47) (0.64–2.26) |
0.86 0.57 |
40/84 21/19 |
0.93 2.54 |
(0.62–1.39) (1.31–4.92) |
0.72 0.01 |
0.96 1.51 |
(0.80–1.16) (1.11–2.05) |
0.70 0.01 |
0.01 | 0.04 | ||
| rs876873 | IVS6−530C>A | TT CT+CC |
369/691 119/269 |
REF REF |
32/69 20/34 |
0.90 1.33 |
(0.58–1.39) (0.73–2.41) |
0.62 0.35 |
38/80 23/21 |
0.93 2.46 |
(0.61–1.39) (1.31–4.63) |
0.71 0.01 |
0.95 1.52 |
(0.79–1.15) (1.14–2.04) |
0.61 0.005 |
0.01 | 0.04 | |||
|
| ||||||||||||||||||||
| Glyphosate |
ALOX5AP
(arachidonate 5-lipoxygenase-activating protein) |
rs9579645 | IVS1+694A>C | AA AC+CC |
151/241 31/91 |
REF REF |
227/433 48/109 |
0.84 1.25 |
(0.64–1.09) (0.73–2.16) |
0.18 0.42 |
200/410 71/120 |
0.78 1.74 |
(0.59–1.02) (1.03–2.93) |
0.07 0.04 |
0.89 1.33 |
(0.77–1.02) (1.03–1.72) |
0.08 0.03 |
0.004 | 0.02 | |
|
| ||||||||||||||||||||
| Atrazine |
LDLR
(low-density lipoprotein receptor) |
rs8110695 | IVS1−4369T>A | TT AT+AA |
128/223 60/150 |
REF REF |
181/307 92/207 |
1.04 1.11 |
(0.78–1.40) (0.75–1.66) |
0.79 0.59 |
154/315 117/199 |
0.86 1.49 |
(0.64–1.16) (1.01–2.19) |
0.33 0.04 |
0.92 1.23 |
(0.79–1.07) (1.02–1.49) |
0.27 0.03 |
0.02 | 0.03 | |
|
LRP1
(low-density lipoprotein receptor-related protein 1) |
rs1800159 | IVS62+86A>G | GG AG+AA |
91/173 98/202 |
REF REF |
117/261 156/254 |
0.85 1.32 |
(0.60–1.19) (0.95–1.82) |
0.34 0.10 |
108/273 165/241 |
0.74 1.46 |
(0.52–1.05) (1.06–2.02) |
0.09 0.02 |
0.86 1.20 |
(0.73–1.02) (1.02–1.40) |
0.09 0.02 |
0.01 | 0.04 | ||
1Accounts for the number of SNPs per gene.
2Risk estimates adjusted for age and state.