Table 1.
Demographic and Clinical Characteristics of the Study Groups
| All N = 228 | No Prior treatment N = 31 | Inadequate prior treatment N = 94 | Adequate AD course N = 80 | Adequate combination course N = 23 | |
|---|---|---|---|---|---|
| Female sex | N (column %) | ||||
| 146 (64.0) | 19 (61.2) | 61 (64.9) | 53 (66.3) | 13 (56.5) | |
| Race | |||||
| White | 189 (82.9) | 26 (83.9) | 78 (83.0) | 68 (85.0) | 17 (73.9) |
| Black | 27 (11.8) | 3 (9.7) | 10 (10.6) | 10 (12.5) | 4 (17.4) |
| Asian | 12 (5.3) | 2 (6.5) | 6 (6.4) | 2 (2.5) | 2 (8.7) |
| Ethnicity | |||||
| Not Hispanic | 200 (87.7) | 26(83.9) | 81 (86.2) | 73 (91.3) | 20 (87.0) |
| Hispanic | 28 (12.3) | 5(16.1) | 13 (13.8) | 7 (8.8) | 3 (13.0) |
| Recruited on inpatient unit | 164 | 19 (61.3) | 80 (85.1) | 54 (67.5) | 11 (47.8) |
| Drop-Outs | 97 (42.5) | 7 (22.6) | 39 (41.5) | 43 (53.8) | 8 (34.8) |
| Mean (SD) | |||||
| Age | 51.5 (17.5) | 57.5 (20.1) | 61.8 (16.2) | 53.4 (14.3) | |
| MMSE | 27.1 (3.4) | 27.7 (2.3) | 27.3(3.4) | 27.2 (3.1) | |
| Duration of current Episode (months) | 7.6 (8.8) | 6.2 (7.1) | 13.4 (24.9) | 23.0 (34.0) | |
| Time in the study trial (weeks) | 8.8 (4.2) | 9.9 (4.1) | 8.6 (4.4) | 8.3 (4.1) | 9.7 (3.9) |
| HDRS-17* - Baseline | 29.8 (6.0) | 30.2 (5.1) | 29.5 (5.3) | 29.4 (5.6) | |
| Post | 11.9 (9.6) | 13.0 (10.7) | 17.6 (8.9) | 17.1 (11.0) | |
| Change | 17.9 (10.7) | 17.3 (10.2) | 11.9 (8.3) | 12.2 (8.1) | |
| % Change | 59.6 (32.1) | 57.9 (32.7) | 40.4 (26.3) | 44.2 (30.8) | |
| HDRS-24*- Baseline | 40.9 (8.5) | 40.9 (8.0) | 40.1 (7.9) | 40.6 (8.5) | |
| Post | 15.4 (13.1) | 17.4 (14.8) | 24.1 (12.2) | 23.4 (15.1) | |
| Change | 25.6 (14.2) | 23.5 (14.8) | 15.9 (11.7) | 17.2 (11.2) | |
| % Change | 62.4 (31.9) | 57.8 (33.7) | 39.8 (27.4) | 45.1 (30.1) | |
| BPRS – Baseline | 54.9 (11.4) | 55.6 (10.4) | 54.1 (9.9) | 57.7 (8.7) | |
| Post | 30.5 (13.5) | 32.4 (14.9) | 38.4 (14.7) | 38.6 (14.6) | |
| Change | 24.4 (14.4) | 23.2 (16.8) | 15.6 (13.1) | 19.2 (15.2) | |
| % Change | 43.9 (20.8) | 40.7 (26.3) | 28.9 (22.3) | 32.5 (26.8) | |
SD: standard deviation; CIRS-G: Cumulative Illness Rating Scale for Geriatrics; MMSE: Mini Mental State Examination; HDRS-17: 17-item version of the Hamilton Depression Rating Scale;
HDRS-24: 24-item version of the Hamilton Depression Rating Scale; BPRS: Brief Psychiatric Rating Scale
*
One participant refused to answer an item; that missing item score was prorated.