Fig. 2. mTOR regulates expression of metabolic genes via transcriptional programs.
Following activation by intrinsic and extrinsic cues, mTOR regulates transcription factors involved in coordinating glycolysis (HIF-1α, Myc), fatty acid oxidation (PPAR α, PPARγ), as well as fatty acid synthesis (SREBP). These same factors have been implicated in regulating T-cell differentiation and function upon antigen recognition.