Table 3.

The specific protein families of targets that TMFS predicted for the top five most promiscuous drugs.

Molecule	Families Targeted
DB02197	Protein kinases (catalytic subunit), HSP90 (N-terminal domain), MutT- like, Matrix metalloproteinases (catalytic domain), Higher-molecular- weight phosphotyrosine protein phosphatases, Motor proteins, Phosphoribulokinase/pantothenate kinase, Tyrosine-dependent oxidoreductases, Aldo-keto reductases (NADP), Galectin (animal S- lectin), Transthyretin (prealbumin)
DB03869	Protein kinases (catalytic subunit), HSP90 (N-terminal domain), Aldo- keto reductases (NADP), NAD-binding domain of HMG-CoA reductase, ITPase (HAM1), G proteins, Carbonic anhydrase, Eukaryotic proteases, PDEase, Nuclear receptor ligand-binding domain
DB02010	Protein kinases (catalytic subunit), Higher-molecular-weight phosphotyrosine protein phosphatases, G proteins, Aldo-keto reductases (NADP), Eukaryotic proteases, GRIP domain, 5′(3′)- deoxyribonucleotidase (dNT-2), DPP6 N-terminal domain-like, BadF/BadG/BcrA/BcrD-like, SH2-domain
DB00686	Protein kinases (catalytic subunit), HSP90 (N-terminal domain), Higher- molecular-weight phosphotyrosine protein phosphatases, G proteins, Phosphoribulokinase/pantothenate kinase, Eukaryotic proteases, Nuclear receptor ligand-binding domain, Cofactor-dependent phosphoglycerate mutase, Fatty acid binding protein-like, Cyclin
DB04700	Protein kinases (catalytic subunit), HSP90 (N-terminal domain), Carbonic anhydrase, Nuclear receptor ligand-binding domain, Purine and uridine phosphorylases, Terpene synthases, Transducin (alpha subunit), Glutathione S-transferase (C-terminal domain), Methionine aminopeptidase