Figure 3.

Specific binding of J591-SPMs to C4-2 prostate cancer cells.

Notes: Confocal images of PSMA-targeted, rhodamine red-containing SPMs containing fluorescent paclitaxel (green, top row) and control IgG-SPMs (bottom row) incubated with C4-2 human prostate cancer cells and stained with DAPI. The last column on the right shows the summed images, which display all three colors for the J591-SPMs, and only shows DAPI staining for the Igg-SPMs.

Abbreviations: PSMA, prostate-specific membrane antigen; SPMs, superparamagnetic iron platinum nanoparticles and paclitaxel in a mixture of PEGylated and biotin-functionalized phospholipids.