Figure 4.

Cytotoxicity measurements of paclitaxel, SPMs, and SMs in C4-2 prostate cancer cells. The graphs show C4-2 cell viability measured with a WST-1 assay after incubation with paclitaxel or SPMs for (A) 24hours, (B) 48hours, and (C) 72hours. Viability after incubation with SPMs (gray bars) and paclitaxel (black bars) is shown as the percentage of viable cells compared with control samples not incubated with particles or drug. (D) Image showing the lack of cytotoxicity when C4-2 human prostate cancer cells are incubated with SIPP micelles without drug (SMs) for 24hours (black bars) and 48hours (gray bars).

Abbreviations: SIPP, superparamagnetic iron platinum nanoparticle; SMs, superparamagnetic iron platinum nanoparticle micelles without drug; SPMs, superparamagnetic iron platinum nanoparticles and paclitaxel in a mixture of PEgylated and biotin-functionalized phospholipids.