Figure 5.

In vivo magnetic resonance imaging and contrast measurements of a mouse bearing a C4-2 xenograft. Longitudinal (A) and transverse (B) contrast percentage measured for mice bearing C4-2 xenografts and injected with either J591-SPMs (diamond, solid gray line), J591-SMs (square, dotted gray line), IgG-SPMs (square, dashed gray line), paclitaxel only (triangle, dashed black line), or nothing (square, solid black line). Representative T₂-weighted magnetic resonance images of a mouse injected with J591-SPMs are shown in (C).

Notes: The arrows point to areas in the C4-2 xenograft that showed dark contrast enhancement at one hour following injection in the middle frame and an area that still showed contrast enhancement 19hours after injection in the far right frame. *P < 0.05.

Abbreviations: SMs, superparamagnetic iron platinum nanoparticle micelles without drug; SPMs, superparamagnetic iron platinum nanoparticles and paclitaxel in a mixture of PEgylated and biotin-functionalized phospholipids.