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. Author manuscript; available in PMC: 2012 Aug 15.
Published in final edited form as: Nat Neurosci. 2011 Jul 31;14(9):1189–1194. doi: 10.1038/nn.2882

Figure 6. Forebrain-specific gene deletion accelerates thalamocortical plasticity.

Figure 6

a, Icam5 normally slows dendritic spine maturation21. b, Icam5 expression at P13 in the auditory thalamocortical slice. Note absence of immunostaining in control MGBv and throughout Icam5−/− brain. Scale bar, 1mm. c, Normalized peak ΔF/F as a function of MGBv stimulus site in Icam5−/− mice for three age groups (median ± s.e.m.; P8–P12, n=8; P13–P15, n=10; P16–P20, n=9). ** P<0.01 (Mann-Whitney U test) between dark grey and black. d, Topographic slope (median ± s.e.m.) for mice without (none, wild-type, n=15; Icam5−/−, n=9) or after 7 kHz exposure between P12–P13 (wild-type, n=9; Icam5−/−, n=7), P13–P14 (Icam5−/−, n=9) or P14–P15 (Icam5−/−, n=9). * P<0.05, ** P<0.01 (Mann-Whitney U test).