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. Author manuscript; available in PMC: 2012 Aug 15.
Published in final edited form as: J Mol Biol. 2007 Sep 20;374(2):487–499. doi: 10.1016/j.jmb.2007.09.035

Figure 7.

Figure 7

(A)–(F) Deuterium exchange in six peptide fragments of the C subunit when bound to Mg2+ATP (x), RIIβ(108–402) and Mn2+AMP-PNP (filled circles)), and RIα; (1–379) with Mg2+ATP(open squares)). (A) Residues 278-289, (B) Residues 247-261, (C) Residues 212-221, (D) Residues 163-172, (E) Residues 133-145, (F) Residues 44-54, (G) Allosteric coupling of αH-αI loop C(residues 278-289) (in purple) and the ATP binding site (Glycine-rich loop C(residues 44-54) (in yellow)), (H) Close-up of αH-αI loop C(residues 278-289) highlighting residues important for interactions between Domain B of RIIβ and the C-subunit.