Table 1.

Roles of MT in hematopoietic cells

Lineage	Cells	Role	Ref.
Undetermined	ES-derived differentiated cells	Overexpression of MT-I gene prevents LIF withdrawal induced apoptosis in ES derived differentiated cells	[64]
Undetermined	human cord blood cells	MT is more highly expressed in mature CD34– cells than in immature CD34+ cells	[67]
Megakaryocyte	Megakaryocytic DAMI cells	Overexpression of MT-IIA resulted in the increase of cell size, intracellular granulation and increment of the megakaryocytic specific CD41 and CD42 and arresting in cell proliferation	[68]
Megakaryocyte, erythroid	K562, DAMI, MEG-01, ELF-153	The more mature K562, DAMI, and MEG-01 cell lines exhibited transcription of all MT isogenes, except MT-III and MT-IV.	[65]
		Phorbol ester induces increased MT transcription and biosynthesis.
Erythroid	K562 cells	EPO- or sodium butyrate-induced differentiation as monitored by hemoglobin formation was inhibited in K562 cells stably transfected with an expression vector containing human MT-IIA gene.	[70]
Erythroid	Rat (acute blood loss, phenylhydrazine induced anemia model)	Induced erythropoiesis or anemia in rats, the induction of MT in the bone marrow is enhanced, with predominant accumulation in erythroblasts	[69]
T lymphoid	T cell line CCRF-CEM	Inhibition of hMTs synthesis by ODNs stimulated the apoptotic process	[71]