Figure 5. Caprine melioidosis vasculitides in multiple organs.

A) pulmonary pyogranuloma encroaching on large interlobular vein, resulting in a segmental leukocytoclastic vasculitis – unaffected endothelium is present on the contralateral side of the vessel; B) pulmonary vasculitis in a medium-sized artery demonstrating a clear separation of the tunica intima from the tunica media by neutrophils and macrophages with segmental intimal proliferation; C) splenic capsular vasculitis with perivascular neutrophilic infiltrate; D) vasocentric renal pyogranuloma showing neutrophil infiltration into the subintima and adventitia with endothelial proliferation and fibrinoid necrosis of a small renal vessel E) focal vasculitis and early pyogranuloma formation at the corticomedullary junction of the adrenal gland; F) leukocytoclastic arteritis in the testicle with an adjacent area of testicular degeneration showing diminished stratification of spermatogenic cells and interstitial suppurative orchitis. 5A–5F, hematoxylin and eosin staining.