TABLE I.

Pediatric T-Cell PTLD After Solid Organ Transplant

	Transplant					Diagnosis of PTLD
	Age and sex	Organ	Immu. supp	After Tx	After PTLD	Disease type	Location	EBV status	Clonality assay	Refs.
1	4 M/f	Lung	Tac, Pred	3 Y	15 M-A	PTL (CD4+)	GI, blood, lung	Neg	FCM+PCR	Yang
2	4 Y/f	Liver	Tac	5 Y	5 M-A	PTL (CD4+)	GI, liver, BM, CSF	Neg	FCM+PCR	Yang
3	5 Y/f	Multi-organ	Tac, cellcept Pred	2 Y	5 M-A	PTL (CD3+)	Graft-GI	Neg	SB	[14]
4	1 Y/m	Liver	CsA, Pred	3 M	1 M	Polymorphous	Brain	Neg	MNR	[15]
5	4 Y/m	Liver	Tac	6 Y	12 M-A	PTL (CD8+)	GI, UR, spleen, brain, pleura	Pos.	PCR	[16]
6	9 D/f	Heart	CsA, Aza	5 Y	2 M	HSGD	BM, liver	Neg	SB+PCR	[17]
7	15 Y/m	Heart	CsA, Aza, Pred, ATG	4 M	3 M	PTL (CD8+) AILD-like?	Blood	Pos	SB	[18]
8	15 Y/f	Liver	Tac, Pred	4 Y	17 M-A	PTL (CD4+)	GI	Pos	PCR	[19]
9	1 M/m	Heart	NR	14 Y	NR	ALCL	Neck LNs	Pos	PCR	[20]
10	12 Y/m	Kidney	Aza, Pred	10 Y	Living	LBL	NR	Neg	SB	[21]
11	14 Y/m	Kidney	Aza, Pred	11 Y	5 M	Diffuse large cell	Renograft, CSF	Neg	SB	[21]
12	5 Y/m	Heart	CsA, Aza, Pred	6 Y	Days	PTL (CD43)	Spleen	Pos	SB	[5]
13	4 Y/f	Kidenys	CsA, siroli	2 Y (4Y)	1 Y (3Y)	B-PTLD (node) T-PTLD (liver, BM)	Liver, BM, LNs	Pos	PCR	[22]
14	14 Y/f	Kidney	CsA	28 Y	1 4D	Agg. LGL-like CD8+	BM	Neg	SB	[4]

m, male; f, female; Y, years; M, months; D, days; LNs, lymph nodes; Tx, transplant; CsA, cyclosporine A; Aza, azathioprine; Pred, prednisone; Tac, tacrolimus; Cellcept, mycophenolate mofetil; MTX, methotrexate; Siroli, sirolimus; -A, alive; NR, not reported; HSGD, hepatosplenic gamma/delta lymphoma; LBL, lymphoblastic lymphoma; FCM, flow cytometry; SB, Southern blot; PCR, polymerase chain reaction; MNR, method not reported.