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Architectural patterns of bone marrow infiltration by plasma cells highlighted by CD138 immunohistochemical stain: (A) interstitial (×200), (B) microaggregates (×100), (C) large nodules (×20), and (D) diffuse (×20). Cytologic patterns of CD138 staining (×1000): intense membranous staining with (E) or without (F) Golgi staining and granular pattern with and without Golgi staining (G). No CD138 expression in plasma cells that demonstrate plasmablastic morphology (H).
