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Induction of mitochondrial autophagy in response to cellular stress. After Drp1-mediated mitochondrial fission, Parkin is recruited to dysfunctional mitochondria where it ubiquitinates proteins. The p62 adaptor protein binds to the ubiquitinated proteins and LC3 on the autophagosomes linking the two organelles. Alternatively, LC3 can directly interact with Bnip3 or Nix on the mitochondria.
