Time-course of SE induced by peripheral paraoxon injection in three groups: no further treatment, diazepam given 10 minutes after the onset of continuous seizures (Blue line) or 30 minutes after the onset of continuous seizures (Red line). In this study, 23 animals were studied, 17 developed continuous seizures, 6 were left untreated (control), 6 received diazepam 10 minutes after the onset of continuous seizures, and 5 received diazepam 30 minutes after the onset of continuous electrographic seizures. Diazepam effectively terminated SE in similar proportion of animals regardless of time of treatment (inset bar charts).