Fig. 4.

THC injection increased serum IgE in the absence of CB1 and CB2. CB^−/− or wild type C57BL/6 mice were pretreated or not 18 hrs prior to immunization with OVA/ALUM. The mice were boosted and sera collected 5–6 days later for ELISA analysis. The IgE levels in non-treated wild-type (normal) and non-treated CB^−/− mice were the same and SR1 treatment only had no effect (data not shown). Data bars are sera from 4–10 mice/group +/− SEM. *=p≤0.05 vs Normal; ** =p≤0.05 vs OVA/ALUM ; #=p≤0.05 vs CB2^−/−OVA/ALUM