Table I.
Induction of colonic gene expression after C. rodentium infectiona
| No. | Fold Change | Accession No. | Gene | Protein |
|---|---|---|---|---|
| 1 | 183 | NM_009114 | S100a9 | S100 calcium-binding protein A9 (calgranulin B) |
| 2 | 136 | NM_013650 | S100a8 | S100 calcium-binding protein A8 (calgranulin A) |
| 3 | 80 | NM_029796 | Lrg1 | Leucine-rich α2-glycoprotein 1 |
| 4 | 35 | NM_009141 | Cxcl5 | Chemokine (C-X-C motif) ligand 5 (LIX) |
| 5 | 35 | NM_011315 | Saa3 | Serum amyloid A3 |
| 6 | 28 | NM_008392 | Irg1 | Immunoresponsive gene 1 |
| 7 | 22 | NM_009140 | Cxcl2 | Chemokine (C-X-C motif) ligand 2 (MIP-2) |
| 8 | 21 | NM_011259 | Reg3a | Regenerating islet-derived 3α |
| 9 | 18 | NM_008361 | Il1b | IL-1β |
| 10 | 17 | NM_011260 | Reg3g | Regenerating islet-derived 3γ |
| 11 | 17 | NM_010819 | Clec4d | C-type lectin domain family 4, member d |
| 12 | 17 | NM_013415 | Atp1b2 | Na+/K+-ATPase β2-subunit |
| 13 | 16 | NM_001033199 | AI747448 | Calcium-activated chloride channel |
| 14 | 15 | NM_001146073 | Hexdc | Hexosaminidase (glycosyl hydrolase family 20) |
| 15 | 14 | NM_008176 | Cxcl1 | Chemokine (C-X-C motif) ligand 1 (KC) |
| 16 | 13 | NM_011036 | Reg3b | Regenerating islet-derived 3β |
| 17 | 12 | NM_009896 | Socs1 | Suppressor of cytokine signaling 1 |
| 18 | 12 | NM_008599 | Cxcl9 | Chemokine (C-X-C motif) ligand 9 (MIG) |
| 19 | 11 | NM_008489 | Lbp | LPS-binding protein |
| 20 | 11 | NM_175449 | Fam26f | Hypothetical protein LOC215900 |
a
Total RNA was extracted from the colon of C. rodentium-infected (week 1) and uninfected C57BL/6J mice and subjected to microarray analysis. Levels of mRNA are expressed as ratio of infected over uninfected tissues (fold change) and are sorted in decreasing order of induction for the top 20 genes.