Mean (SEM) proteinuria in (A) male (M) and (B) female (F) rats measured on days −1, 3, 6, 9, and 13 of the study and expressed as micrograms protein excreted per day per gram of body weight (BW). Ang II = angiotensin II infusion (80 ng/min for 14 d); Ang II + HS = angiotensin II infusion plus high-salt diet; Ang II + HS + Cand = angiotensin II infusion plus high-salt diet plus candesartan (25 mg/L in the drinking water); HS = high-salt diet (8% NaCl); NS = normal-salt diet. *P < 0.01, compared with same-sex normal-salt control (NS). †P < 0.05 M: Ang II + HS vs M Ang II + HS + Cand. ‡P < 0.05; §P < 0.05 compared with opposite sex same treatment group.