Without adMSC, HMEC do not organize into vessels and disappear over time. Photographs of HMEC-only explants appear opaque and avascular at day 3, 7, and 14 (A). UEA-1 lectin staining (B) shows that without adMSC, HMEC remain on the module surface (day 3) and the UEA-1 staining diminishes over time suggesting cell death (day 7). By day 14, no HMEC can be found. Higher magnification UEA-1 images (C) show HMEC disappearance over time. Arrows highlight some UEA-1 staining, with some modules highlighted by dashed lines. Color images available online at www.liebertpub.com/tea