FIG. 4.

adMSC cotransplantation enhances host tissue angiogenesis into the modular construct. Micrographs of HMEC-only and HMEC+adMSC modules stained for CD31(mouse) show the progressive infiltration of host-derived vessels into the modular construct. At day 3, CD31+ vessels (some highlighted with arrows) were seen at the edge of the modular construct in both the HMEC-only and HMEC+adMSC case (some modules highlighted by dashed circles). By day 7, CD31+ vessels were seen infiltrating into the HMEC+adMSC but not in the case without adMSC. By day 14, many larger CD31+ vessels have infiltrated into the HMEC+adMSC construct while the case without adMSC remains relatively avascular. Scale bar=100 μm. Color images available online at www.liebertpub.com/tea