Figure 2.

Effects of flupirtine on heterologously expressed K_V7 channels. Human K_V7.2 and 7.3 were co-expressed in tsA cells. Currents were evoked by ramp hyperpolarizations from −25 to −100 mV during periods of 1 s. (A) Representative current traces in the presence of solvent and 3 or 30 µM flupirtine, respectively. (B) Current amplitudes were determined at −30 mV in the presence of solvent or increasing concentrations of flupirtine; the average of normalized current amplitudes is shown for seven cells.