Table 1.

Effects of flupirtine on voltage gated Na⁺ and Ca²⁺ channels

		10 µM flupirtine			30 µM flupirtine
Current	Neuron	Normalized amplitude	n	P	Normalized amplitude	n	P
INa	DRG	0.95 ± 0.05	5	>0.05	0.77 ± 0.04	5	<0.05
	HC	1.00 ± 0.03	4	>0.05	0.99 ± 0.03	4	>0.05
ICa	DRG	0.84 ± 0.05	7	>0.05	0.78 ± 0.08	7	>0.05
	HC	0.98 ± 0.02	6	>0.05	0.72 ± 0.11	6	<0.05

Na⁺ and Ca²⁺ currents were elicited by depolarizations from −80 to +10 mV in either hippocampal or DRG neurons. Normalized peak current amplitudes in the presence of 10 or 30 µM flupirtine were compared with those in the presence of solvent (not shown). P values for significances of differences versus solvent were calculated by a Kruskal–Wallis ANOVA followed by Dunn's post hoc test.