Figure 6.

Proposed signalling model of the essential role of PI3Kγ in MCP-1-stimulated aortic smooth muscle cell as an amplifier of PDGF-induced cell migration. In aortic SMC migration, PI3Kγ is the major PI3K isoform implicated in MCP-1-induced PKB (Akt) phosphorylation. Moreover, PI3Kγ could play a role as an amplifier of PDGF-induced SMC migration by an autocrine/paracrine pathway. MCP-1 mRNA level is increased upon PDGF stimulation leading to MCP-1 secretion and CCR2 activation. Dashed lines indicate potential signalling mechanism not fully established at this time. Abbreviation: TKR, tyrosine kinase receptor; PDGF-RE, PDGF-responsive-element.