Table 1.

Amino acid sequence of µ-conotoxins, origin and known targets to date

Name	Sequence	Clade/species	Target	References
		Gastridium
µ-GIIIA	RDCCTPP--KK-CKDRQCKPQ-RCCA*	Conus geographus	NaV1.4	Cruz et al. (1985)
µ-GIIIB	RDCCTPP--RK-CKDRRCKPM-KCCA*	C. geographus	NaV1.4, NaV1.2, NaV1.3	Cruz et al. (1985); Lewis et al. (2007)
µ-GIIIC	RDCCTPP--KK-CKDRRCKPL-KCCA*	C. geographus	NaV1.4	Cruz et al. (1985)
µ-TIIIA	RHGCCKGP--KG-CSSRECRPQ-HCC*	C. tulipa	NaV1.4, NaV1.2	Lewis et al. (2007)
		Chelyconus
µ-PIIIA	ZRLCCGFP--KS-CRSRQCKPH-RCC*	C. purpurascens	NaV1.4, NaV1.2, hNaV1.7	Safo et al. (2000); Nielsen et al. (2002)
		Pionoconus
µ-CnIIIA	GRCCDVP--NA-CSGRWCRDHAQCC*	C. consors	fTTX-R	Zhang et al. (2006)
µ-CnIIIB	QGCCGEP--NL-CFTRWCRNNARCCRQQ	C. consors	fTTX-R	Zhang et al. (2006)
µ-CnIIIC	ZGCCNGP--KG-CSSKWCRDHARCC*	C. consors	NaV1.4, NaV1.2, α3β2 nAChRs	This work
µ-CIIIA	GRCCEGP--NG-CSSRWCKDHARCC*	C. catus	fTTX-R, fTTX-S	Zhang et al. (2006)
µ-MIIIA	QGCCNVP--NG-CSGRWCRDHAQCC*	C. magus	fTTX-R	Zhang et al. (2006)
µ-SIIIA	QNCCN----GG-CSSKWCRDHARCC*	C. striatus	NaV1.2, NaV1.4, fTTX-R	Bulaj et al. (2005); Schroeder et al. (2008)
µ-SIIIB	QNCCN----GG-CSSKWCKGHARCC*	C. striatus	NaV1.4, NaV1.2	Schroeder et al. (2008)
		Textilia
µ-BuIIIA	VTDRCC--K-GKRECG-RWCRDHSRCC*	C. bullatus	NaV1.4	Holford et al. (2009)
µ-BuIIIB	VGERCC--KNGKRGCG-RWCRDHSRCC*	C. bullatus	NaV1.4	Holford et al. (2009)
µ-BuIIIC	IVDRCCNKGNGKRGCS-RWCRDHSRCC*	C. bullatus	NaV1.4	Holford et al. (2009)
µ-SmIIIA	QRCCNG---RRGCSSRWCRDHSRCC*	C. stercusmuscarum	fTTX-R	West et al. (2002)
		Asprella
µ-KIIIA	CCN-------CSSKWCRDHSRCC*	C. kinoshitai	NaV1.2, NaV1.4, NaV1.1, NaV1.6, NaV1.7, fTTX-R	Bulaj et al. (2005); Zhang et al. (2007)

^*Indicates C-terminal amidation. Sequence alignment was manually performed and cysteine residues are highlighted in blue.

All target channels are from rat except hNa_V1.7 (human), fTTX-R (frog) and mNa_V1.7 (mouse).