Table 2. Correlation of distinct epitopes of BARD1 and BRCA1 expression with survival in 75 colorectal cancer patients.
1-year survival
|
2-year survival
|
3-year survival
|
||||||
---|---|---|---|---|---|---|---|---|
Expression pattern | No. of patients | Median survival | % | P -value | % | P -value | % | P -value |
N neg vs pos | 55 vs 20 | 11 vs 26 | 47.3 vs 85.0 | 0.0035 | 21.8 vs 50.0 | 0.0178 | 12.7 vs 40.0 | 0.009 |
P neg vs pos | 14 vs 61 | 14 vs 15 | 57.1 vs 57.4 | 0.9873 | 28.6 vs 29.5 | 0.9446 | 21.4 vs 19.7 | 0.8822 |
W neg vs pos | 4 vs 71 | |||||||
C neg vs pos | 42 vs 33 | 9 vs 17 | 45.2 vs 72.7 | 0.0169 | 21.4 vs 39.4 | 0.0898 | 11.9 vs 30.3 | 0.048 |
BRCA1 neg vs pos | 60 vs 15 | 16 vs 12 | 60.0 vs 46.7 | 0.3504 | 31.7 vs 20.0 | 0.3747 | 23.3 vs 6.7 | 0.1489 |
Note: ‘neg’, negative staining; ‘pos’, positive staining.
Antibody abbreviations: N - N19, P - PVC, C - C20, W - WFS. For WFS, negative staining cases were not enough for further analysis.