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. 2012 Jul 10;107(4):739–747. doi: 10.1038/bjc.2012.301

Figure 1.

Figure 1

Breakpoint mapping by metaphase BAC FISH. The panels show hybridisation to der(8) and der(12) in MS751 metaphase spreads of BAC probes (labelled blue or green) that mapped to the selected 1-Mb regions on 8p21.3 (A) and 12p13.31 (B). For each probe, the reciprocal chromosome in the translocation (i.e., chromosome 12 in (A) and chromosome 8 in (B)) was labelled in red. Where a BAC did not hybridise to a derivative chromosome, the image is not shown. The BACs that hybridised to both der(8) and der(12) (i.e., ‘splitting’ BACs) were the chromosome 8 BAC RP11-70F13 (A) and the chromosome 12 BACs RP11-273B20 and RP11-653C9 (B).