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|
Ctrough, μg ml−1
(from cycle 3) | ||||
|---|---|---|---|---|
| Dose (mg kg−1) | Number of patients | Free aflibercept | VEGF-bound aflibercept | Free/bound ratio |
| 4 | 6 | 4.19 (84) | 3.80 (26) | 1.08 (83) |
| 5 | 7 | 7.58 (74) | 4.14 (22) | 1.58 (65) |
| 6 | 15 | 4.94 (107) | 3.71 (28) | 1.30 (108) |
Abbreviations: Ctrough=concentration before dosing; CV=coefficient of variation; VEGF=vascular endothelial growth factor.
